My son has ring of fire ADHD and sensory issues. These patches are awesome. A friend recommended them to me after her doctor mentioned them as an option. He can focus and it gives him even amounts throughout the day. They cross the blood brain barrier well. They are very discreet and have no icky side effects like gas from some of the otc supplements we've tried. We put one on in the morning and he heads off to school. He's a little tired and you can tell it is wearing off by the end of the day, but he's doing great. He has hyperactivity and all of the supplements recommended for his type of ADHD, (there are 7 types),almost all the recommended supplements are listed on the ingredients of these patches. Of course every person is different, but with a money back guarantee what do you have to lose? We noticed the difference the first day, and about a week in I forgot to put one on him and he said he "froze" that day and had problems. I told him I forgot and he said "Oh, that explains it!" So it definitely wasn't some kind of placebo effect. Praise God we feel like we can enjoy our son and he is doing awesome in school. He went from throwing himself against the walls this Summer just to get enough sensory input, to a wonderful 3rd grade boy who is able to let his big brain work for him instead of against him. Thank you Patch MD!